Undenatured Chicken Collagen type ii for Joint Health

The undenatured type ii collagen is an ingredient containing native collagen type II produced from chicken sternum. The Triple helix spatial structure of collagen was maintained by a scientific production process which means the collagen is not denatured and is able to function in many ways to help maintains the health structure of joint cartilages.

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Quick features of Undenatured Chicken Collagen type ii

Material name Undenatured Chicken Collagen type ii for Joint Health
Origin of material Chicken sternum
Appearance White to slight yellow powder
Production process Low temperature hydrolyzed process
Undenatured type ii collagen >10%
Total protein content 60% (Kjeldahl method)
Moisture content ≤10% (105°for 4 hours)
Bulk density >0.5g/ml as bulk density
Solubility Good solubility into water
Application To produce Joint care supplements
Shelf Life 2 years from production date
Packing Inner packing: Sealed PE bags
Outer packing: 25kg/Drum

What is Undenatured chicken collagen type ii?

Undenatured chicken collagen type II is the type II collagen produced from Chicken sternum under a well controlled and developed production process so that the protein of the collagen is undenatured. The word "Undenatured" means the molecular structure of the type ii collagen remains in original Triple Helix Structure as the way it is in the animal body even after it is extracted and stabilized from the chicken sternum.

The Undenatured chicken collagen type ii is active collagen which remains in its original active molecule structure while the denatured collagen lost its activity by hydrolyzation process. The activity molecule of collagen is critical for collagen to function in immune response to some type of inflammation of joint diseases.

The type II collagen itself is the main structure of collagen in the joint cartilages. The Glycosaminoglycan in the type ii collagen is an important component of bone and articular cartilage of synovial joint cavity. It helps promote the repairing of cartilages and joint lubrication.

Specification of Chicken Collagen Type ii

Appearance White to off white powder
Total Protein Content 50%-70% (Kjeldahl Method)
Undenatured Collagen type II ≥10.0% (Elisa Method)
Mucopolysaccharide No less than 10%
pH 5.5-7.5 (EP 2.2.3)
Residual on Ignition ≤10%(EP 2.4.14 )
Loss on drying ≤10.0% (EP2.2.32)
Heavy Metal < 20 PPM(EP2.4.8)
Lead <1.0mg/kg( EP2.4.8)
Mercury <0.1mg/kg( EP2.4.8)
Cadmium <1.0mg/kg( EP2.4.8)
Arsenic <0.1mg/kg( EP2.4.8)
Total Bacteria Count <1000cfu/g(EP.2.2.13)
Yeast & Mold <100cfu/g(EP.2.2.12)
E.Coli Absence/g (EP.2.2.13)
Salmonella Absence/25g (EP.2.2.13)
Staphylococcus aureus Absence/g (EP.2.2.13)

Competitive Advantages of our undenatured collagen type ii

1. High content of undenatured collagen type ii: Our undenatured collagen type ii is produced by a unique production process, which maintains the activity of the collagen and at the same time purify the material to contain a high content of undenatured collagen. Other manufacturers might contain around 3%, 9% undenatured collagen type ii which we can supply up to 25% undenatured collagen type ii.

2. High Bulk density with good flowability: Our undenatured collagen type II is of a high bulk density of around 0.5g/ml as well as good flowability, which makes it suitable to produce either tablets or capsules.

3. GMP Quality: The collagen powder we supplied is produced in GMP facility according to GMP requirements. It is tested in our own laboratory before we release the goods to you.

How Does Undenatured chicken collagen type ii work for joint health?

1. Help reduces the inflammation caused by an immune response against endogenous type II collagen, which is known as autoimmune intolerance.

The Undenatured collagen type II retains the natural triple helix structure which retains an antigenic factor, which makes the collagen possess an ability of antigen-antibody binding. The rheumatoid arthritis happens when the body produce some antibodies against autoantigens. The latest research shows that taking a low dose of active type II collagen will induce the body to consider type II protein as a self-antigen, which will prevent the generation of autoantibody. In this way, it will slow down the disorders of rheumatoid arthritis.

2. The Undenatured collagen type ii contains abundant glycosaminoglycans. The combination of glycosaminoglycans and core proteins help promote the generation of proteoglycans in cartilages. In this way, the active collagen type II restores the balance of cartilage tissue reconstruction as well as repairs the damaged cartilages.

3. The Undenatured collagen type ii contains more hydroxyproline than normal type i collagen, which is more conducive to the adhesion of calcium, phosphorus and other mineral components to constitutes bones. Thus, it is widely used as ingredient for joint health supplements.

Scientific study of undenatured chicken collagen type II

The scientific study proves that the AC-II provides benefits for joint health. The clinical study on the animals proves that benefits of AC-II are confirmed in trials of traumatic osteoarthritis, post-traumatic and obesity-induced arthritis of rats.

In the post-traumatic osteoarthritis trial, joint damage resulted in the loss of cartilage (matrix and chondrocytes) and severe local inflammation of the knee joint. After taking low-dose Active Collagen II, the following benefits were clearly proved:

1. Prevent Cartilage Degradation and Lubrication
AC-II can protect cartilage and reduce degenerative changes (normalization of chondroitin region, blue bars on the left side of the diagram below), stimulates proteoglycan synthesis in chondrocytes and promotes joint lubrication (the percentage of activated chondrocytes increases, as shown in the blue histogram on the right side of the diagram below).

Undenatured Chicken Collagen type ii for Joint Health1

Diagram No.1: Undenatured Chicken Collagen type ii Prevents cartilage degradation and promotes the synthesis of lubricating matrices.

2. Reduce the inflammation
Undenatured chicken collagen type ii promotes the anti-inflammatory effect of knee joints (reduces the expression of local inflammatory markers in the synovial membrane, See blue histogram in below diagram).

Reduce the inflammation

Diagram No.2: Undenatured chicken collagen type ii reduces the inflammation of OA.

3. Prevent OA (Osteoarthritis)
In the obese and traumatic osteoarthritis trial, the loss of knee joint cartilage (matrix and chondrocytes) and the local inflammatory response were transiently induced. Low-dose
Undenatured chicken collagen type ii supplementation can prevent osteoarthritis in below aspects:

Experiments on mice that are obese by high-fat diets have shown protection of cartilage, reduction of degenerative changes (Cartilage zone normalization, blue histogram on the left side of the diagram below), and promotion of joint lubrication by stimulating proteoglycan synthesis in chondrocytes (The percentage of activated chondrocytes increases, the blue histogram on the right side of the diagram below).

Prevent OA (Osteoarthritis)

Diagram No.3 : Undenatured chicken Collagen type ii prevents the degradation of cartilage and promotes the synthesis of a lubricating matrix in the osteoarthritis caused by obesity.

4. High bioavailability
The study shows that 1 hour after taking Undenatured type ii the hydroxyproline in mouse serum reaches a high concentration, which proves that Undenatured chicken type ii has a high bioavailability.

High bioavailability

Diagram 4: Undenatured chicken Collagen type ii can be absorbed by body efficiently.

Application of Undenatured chicken collagen type ii

Typically, the undenatured collagen type II is used to produce hard capsule containing Undenatured type ii chicken collagen. It might be used together with other joint health ingredients such as chondroitin sulfate, glucosamine and hyaluronic acid.

The most popular finished dosage form for undenatured chicken collagen type ii is Bone and joint health capsules. Our undenatured chicken collagen type ii has good flowability and can be filled into capsules easily.

Commercial term:  MOQ, sample and price
Packing: Our packing is 25KG/Drum for big commercial orders. For small quantity order, we can do packing like 1KG,5KG, or 10KG, 15KG in an Aluminum foil bags.

Sample Policy: We can provide up to 30 grams free of charge. We usually send the samples via DHL, if you have a DHL account, please kindly share with us.

Price: We will quote the prices based on different specifications and quantities.

Custom Service: We have dedicated sales team to deal with your inquiries. We promise you will sure get a response within 24 hours since you send a inquiry.

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