Native Chicken Collagen type ii for Bone Health

Native Collagen type ii is type ii collagen produced from chicken sternum cartilages. The key feature of native collagen type ii is that it contains active type ii collagen which is extremely helpful for joint and bone health. Our native chicken collagen type ii is used for production of supplements in capsule form.

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Quick features of Native Chicken Collagen type ii

Material name Undenatured Chicken Collagen type ii for Joint Health
Origin of material Chicken sternum
Appearance White to slight yellow powder
Production process Low temperature hydrolyzed process
Undenatured type ii collagen >10%
Total protein content 60% (Kjeldahl method)
Moisture content ≤10% (105°for 4 hours)
Bulk density >0.5g/ml as bulk density
Solubility Good solubility into water
Application To produce Joint care supplements
Shelf Life 2 years from production date
Packing Inner packing: Sealed PE bags
Outer packing: 25kg/Drum

What is Native chicken collagen type ii?

Native type II collagen is an active type II collagen produced by low-temperature extraction manufacturing technology.

Native type II collagen is an active type II collagen produced by low-temperature extraction manufacturing technology. The biggest feature is the specific activity of the protein. The triple-helix spatial structure of the type II protein, which is critical for joint health, is preserved intact.

The active type II collagen produced by patented technology can reach the small intestine of the human body intact, so as to be absorbed and avoid misjudgment by the immune system. It works to repair damaged and strengthen cartilage tissue.

Specification of Native Chicken Collagen Type ii

Appearance White to off white powder
Total Protein Content 50%-70% (Kjeldahl Method)
Undenatured Collagen type II ≥10.0% (Elisa Method)
Mucopolysaccharide No less than 10%
pH 5.5-7.5 (EP 2.2.3)
Residual on Ignition ≤10%(EP 2.4.14 )
Loss on drying ≤10.0% (EP2.2.32)
Heavy Metal < 20 PPM(EP2.4.8)
Lead <1.0mg/kg( EP2.4.8)
Mercury <0.1mg/kg( EP2.4.8)
Cadmium <1.0mg/kg( EP2.4.8)
Arsenic <0.1mg/kg( EP2.4.8)
Total Bacteria Count <1000cfu/g(EP.2.2.13)
Yeast & Mold <100cfu/g(EP.2.2.12)
E.Coli Absence/g (EP.2.2.13)
Salmonella Absence/25g (EP.2.2.13)
Staphylococcus aureus Absence/g (EP.2.2.13)

What is the differences between hydrolyzed collagen and undenatured type ii collagen?

Molecular structure differences
Generally speaking, the molecular structure of hydrolyzed collagen is destroyed while the undenatured type ii collagen keeps in a triple helix molecular structure. Hydrolyzed collagen is the collagen peptides consisted of short chains of amino acids. The three long chains of amino acids are cut into short amino acid chains. But the molecular structure of undenatured collagen type ii is original triple helix structure, the three long chais of amino acids are not broken.
Function differences
The function of Hydrolyzed collagen mainly comes from amino acids nutrition values. The hydrolyzed collagen contains Hydroxyproline and glycine. Hydroxyproline works as a transportation tool to carry the calcium and phosphorus into cells of bones to form the bones.
However, the undenatured collagen type ii contains other important substances such as chondroitin sulfate, glucosamine and hyaluronic acid. It functions much better than hydrolyzed collagen.

Scientific study of undenatured chicken collagen type II

The scientific study proves that the AC-II provides benefits for joint health. The clinical study on the animals proves that benefits of AC-II are confirmed in trials of traumatic osteoarthritis, post-traumatic and obesity-induced arthritis of rats.

In the post-traumatic osteoarthritis trial, joint damage resulted in the loss of cartilage (matrix and chondrocytes) and severe local inflammation of the knee joint. After taking low-dose Active Collagen II, the following benefits were clearly proved:

1. Prevent Cartilage Degradation and Lubrication
AC-II can protect cartilage and reduce degenerative changes (normalization of chondroitin region, blue bars on the left side of the diagram below), stimulates proteoglycan synthesis in chondrocytes and promotes joint lubrication (the percentage of activated chondrocytes increases, as shown in the blue histogram on the right side of the diagram below).

1.Prevent Cartilage Degradation and Lubrication

Diagram No.1: Undenatured Chicken Collagen type ii Prevents cartilage degradation and promotes the synthesis of lubricating matrices.

1. Reduce the inflammation
Undenatured chicken collagen type ii promotes the anti-inflammatory effect of knee joints (reduces the expression of local inflammatory markers in the synovial membrane, See blue histogram in below diagram).

1.Prevent Cartilage Degradation and Lubrication1

Diagram No.2: Undenatured chicken collagen type ii reduces the inflammation of OA.

2. Prevent OA (Osteoarthritis)
In the obese and traumatic osteoarthritis trial, the loss of knee joint cartilage (matrix and chondrocytes) and the local inflammatory response were transiently induced. Low-dose
Undenatured chicken collagen type ii supplementation can prevent osteoarthritis in below aspects:

Experiments on mice that are obese by high-fat diets have shown protection of cartilage, reduction of degenerative changes (Cartilage zone normalization, blue histogram on the left side of the diagram below), and promotion of joint lubrication by stimulating proteoglycan synthesis in chondrocytes (The percentage of activated chondrocytes increases, the blue histogram on the right side of the diagram below).

2. Prevent OA (Osteoarthritis)

Diagram No.3 : Undenatured chicken Collagen type ii prevents the degradation of cartilage and promotes the synthesis of a lubricating matrix in the osteoarthritis caused by obesity.

3. High bioavailability
The study shows that 1 hour after taking Undenatured type ii the hydroxyproline in mouse serum reaches a high concentration, which proves that Undenatured chicken type ii has a high bioavailability.

3. High bioavailability

Diagram 4: Undenatured chicken Collagen type ii can be absorbed by body efficiently.


Packing: Our packing is 25KG/Drum for big commercial orders. For small quantity order, we can do packing like 1KG,5KG, or 10KG, 15KG in a Aluminum foil bags.
Sample Policy: We can provide up to 30 grams free of charge. We usually send the samples via DHL, if you have a DHL account, please kindly share with us.
Price: We will quote the prices based on different specifications and quantities.
Customer Service: We have dedicated sales team to deal with your inquiries. We promise you will sure get a response within 24 hours since you send a inquiry.

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